Advances in pharmacogenomics of cytochrome P450 oxidoreductase

Abstract

Abstract: The redox reaction of the cytochrome P450 enzymes (CYP) are important physiological and biochemical reactions in the human body, involved in the metabolism of endogenous and exogenous compounds and steroids synthesis. POR (cytochrome P450 oxidoreductase) is the only electron donor for all the hepatic microsomal CYP enzymes. Not only acts as an electron donor involved in drug metabolism mediated by CYP enzymes, POR also directly induces the transformation and metabolism of some anti-tumor precursors. Therefore POR plays an important role in drug metabolism. The gene encoding human POR is highly polymorphic, which is of great clinical significance by having an significant effect on the metabolism and even curative effects of clinically used drugs. Studies on the pharmacogenomics of POR in recent years are summarized as follows.

Key words: Cytochrome P450 oxidoreductase, Pharmacogenomics, Cytochrome P450 enzymes, Electron donor, Genetic polymorphism, Drug metabolism

CLC Number:

R968

HU Lei, GAO Li-chen, ZHUO Wei, ZHOU Hong-hao, FAN Lan. Advances in pharmacogenomics of cytochrome P450 oxidoreductase[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(7): 821-827.

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