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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2018, Vol. 23 ›› Issue (2): 217-222.doi: 10.12092/j.issn.1009-2501.2018.02.019

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Research progress of general anesthesia in the pharmacogenetics

XIE Shangchen 1,2, LI Wei 1,2, LIAO Ping 1,2, HE Yijing 1,2, MCLEOD Howard L.1,2   

  1. 1 Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; 2 Institute of Clinical Pharmacology Central South University,Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, Hunan, China
  • Received:2017-11-07 Revised:2018-01-05 Online:2018-02-26 Published:2018-03-02

Abstract:

General anesthesia is a state of unconsciousness, amnesia, analgesia and akinesia induced by drugs used in general anesthesia. Along with the development of pharmacogenetics and pharmacogenomics, pharmacogenetic studies of these drugs have been carried out continuously. This review summarizes the pharmacogenetics of commonly used general anesthesia drugs like analgesics, sedative-hypnotics, neuromuscular blockers and antiemetics in recent years.

Key words: general anesthesia, pharmacogenetics, pharmacogenomics

CLC Number: