Effects of garlicin on 5-HT, β-EP of mice at the different age groups

Abstract

Abstract: AIM: To explore the effects of garlicin on 5-HT, β-EP of mice at the different age groups.METHODS: The mice were randomly divided into young group and senium group, and each group consists of treatment group and control group. Aging models of mice were with D-galactose. The mice in treatment group were administered orally with garlicin for consecutive 14 days and two other groups with equal amount of normal saline. The content of 5-HT and β-EP were detected by enzyme-linked immunosorbent assay (ELISA).RESULTS: The β-EP content were lower in the senium groups those that in young groups (P＜0.05). The difference of 5-HT was not signifi cant between senium group and young group(P＞0.05). Garlicin improved the levels of 5-HT and β-EP in the young treatment groups(P＜0.05). Compared with senium control group, the level of β-EP was higher in senium treatment group(P＜0.05), but the difference of 5-HT was not signifi cant between the two groups(P＞0.05).CONCLUSION: Garlicin can improve the level of β-EP of mice, and it can improve the level of 5-HT of young mice.

Key words: Garlicin, Aging model, 5-HT, β-EP, Neuro-endocrine-immunoregulatory network(NEI)

CLC Number:

R965.2

LV Ya-nan, DONG Qun. Effects of garlicin on 5-HT, β-EP of mice at the different age groups[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(8): 884-887.

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