Abstract: AIM: To compare the muscle relaxant effect of different doses Rocuronium on acute hypervolemic hemodilution.METHODS: Ninety elective 80 cases orthopedic surgery patients, ASA Ⅰ-Ⅱ, 35 to 60 years old, were randomly divided into two groups by the different treatment methods in preoperative transfusion ( n=40 each ): group A acute hypervolemic hemodilution (AHH) and control group ( group B). Each group was divided into two subgroups(n=20 each) with the corresponding loading dose of Rocuronium (0.6, 0.9 mg/kg). Two groups of patients were conducted hemodilution or conventional infusion before induction of anesthesia.The block onset time,the TOF of no response,the block duration,the recovery index of muscle relaxants,and the muscle relaxation time in vivo correlation time left were observed in subgroups.RESULTS: The same dose compared with the control group, the block onset time extension, the TOF of no response, neuromuscular blockade duration, significantly shorter duration of action in vivo (P<0.05), and high-dose group was significantly shorter more (P<0.01). Recovery index and the relevant time of residual neuromuscular did not change significantly (P>0.05).CONCLUSION: Both doses of rocuronium in neuromuscular monitoring can successfully intubated,inversely proportional to dose and duration of intubation. AHH can reduce the pharmacodynamics of rocuronium.

Key words: Acute hypervolemic hemodilution, Rocuronium, Pharmacodynamics