Correlation study of visfatin and gestational diabetes mellitus

Abstract

Abstract: AIM: To explore the relationship between visfatin and gestational diabetes mellitus by detecting the level of visfatin in gestational diabetes mellitus patients.METHODS: 60 primiparae patients with singleton birth were randomly selected from the forth people's hospital of wuxi from June of 2011 to June of 2012 and were individed into gestational diabetes mellitus group and control group(each group n=30).The essential information of all patients were recorded and the levels of fasting plasma glucose,fasting insuline,blood fat(cholesterol and triglyceride),visfatin were detected,and the insulin resistance index and BMI were calculated.RESULTS: Compared to the control group,the levels of the fasting plasma glucose,fasting plasma insulin, maternal weight gain,triglyceride,the insulin resistance index and the BMI of prior to delivery were increased significantly in gestation diabetes mellitus group,there were statistically significant difference (P<0.05). Compared to the control group,the level of cholesterol was increased,but there was no statistically significant difference (P>0.05).CONCLUSION: The maternal level of visfatin are increased in gestation diabetes mellitus,which suggests visfatin maybe involves in the pathogenic mechanism of gestation diabetes mellitus.

Key words: Visfatin, Gestation diabetes mellitus, Insulin resistance

CLC Number:

R587.1

SONG Jing, WU Ping, WANG Xi-mei. Correlation study of visfatin and gestational diabetes mellitus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1406-1409.

References

[1] Coskun A,Ozkaya M,Kiran G,et al.Plasma visfatin levels in pregnant women with normal glucose tolerance,gestational diabetes and pre-gestational diabetesmellitus[J].J matern Fetal Neonatal Med,2010,23(9):1014-1048.
[2] Fukuhara A,Matsuda M,Nishizawa M,et al.Visfatin: a protein secreted by visceral fat that mimics the effects of insulin[J].Science,2005,307(5708):426-430.
[3] Gok DE,Yazici M,Uckaya G,et al.The role of Visfatin in the pathogenesis of gestational diabetes mellitus diabetes mellitus[J]. J Endocrinol Invest,2011,34(1):3-7.
[4] American Diabetes Association. Standards of medical care in diabetes-2010[J]. Diabetes Care, 2010,33(suppl 1):S11-61.
[5] Hug C,Lodish HF. Visfatin:a new adipokine[J]. Science,2005,307(5708):366-367.
[6] Jian WX, Luo TH, Gu YY, et al. The visfatin gene is associated with glucose and lip id metabolism in a Chinese population[J].Diabet Med,2006,23(9):967-973.
[7] Pagano C, Pilon C, Olivieri M, et al. Reduced plasma visfatin /pre β-cell colony enhancing factor in obesity is not related to insulin resistance in humans[J].J Clin Endocrinol Metab,2006,91(8):3165-3170.
[8] Chen MP, Chung FM, Chang DM, et al. Elevated plasma level of visfatin / Pre β-cell colony-enhancing factor in patients with type 2 diabetes mellitus[J].J Clin Endocrinol Metab,2006,91(1):295-299.
[9] HaiderDG, Schindler K, Schaller G, et al. Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding[J]. J Clin Endocrinol Metab,2006,91(4):1578-1581.
[10] Varma V, Yao Borengasser A, Rasouli N, et al. Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipid and inflammation[J]. J Clin Endocrinol Metab,2007,92(2):666-672.
[11] Berndt J,Kloting N,Kralisch S,et al.Plasma visfatin concentrations and fat depot-specific mRNA expression in humans[J]. Diabetes,2005,54(10):2911-2916.
[12] Chan TF,Chen YL, Lee CH,et al. Decreased plasma visfatin concentrations in women with gestational diabetes mellitus[J]. J Soc Gynecol Investig,2006,13(5):364-367.
[13] López-Bermejo A,Chico-Julià B,Fernàndez-Balsells M,et al.Serum visfatin increases with progressive β-cell deterioration[J]. Diabetes,2006,55(10):2871-2875.
[14] Ognjanovic S, Ku TL, Bryant-Greenwood GD. Pre β-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium[J].Am J Obstet Gynecol,2005,193(1):273-282.
[15] Morgan SA, Bringolf JB,Seidel ER. Visfatin expression is elevated in normal human pregnancy[J].Peptide,2008,29(8):1382-1389.