The role of the endoplasmic reticulum chaperone tapasin in mediating specific CTL responses

Abstract

Abstract: The clearing of virus and tumor cell a large degree relied on Specific CD8+ cytotoxic T lymphocytes (cytotoxic T cell, CTL). CTL recognised virus peptide paragraph through T cell receptor (TCR) and caused infection cell melting through MHC-I class molecular presenting. The assembly of classic MHC-I molecular composition in endoplasmic reticulum (ER) required antigen peptide ligand and beta 2m,and this process need chaperones such as tapasin. Tapasin was offspring of transporters associated with antigen processing (TAP) and a member of the immunoglobulin superfamily as well as MHC-I. Tapasin as molecular bridges between TAP and MHC-I, have an important role in mediated specific CTL reactions. This review resumes its biological characteristics, the role in mediated specific CTL reactions and contacting with diseases.

Key words: Tapasin, Cytotoxic T cell, MHC-I, Antigen processing

CLC Number:

R966

TANG Yu-yan, CHEN Xiao-hua, YU Yong-sheng. The role of the endoplasmic reticulum chaperone tapasin in mediating specific CTL responses[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(2): 212-216.

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