Abstract: AIM: To observe the dynamic changes of serum levels of platelet derived growth factor (PDGF) in the patients with intracerebral hemorrhage.METHODS: A total of 78 patients with intracerebral haemorrhagia (internal capsule) were enrolled in this study. The serum PDGF was determined by enzyme-iineked immunosorbent assay (ELISA). The degree of neural function defect was analysed by NIHSS appraise. The perihematomal edema volumes was evalulated by CT. The expression of PDGF in platelets was detected by flow cytometric analysis.RESULTS: The serum concentration of PDGF was significantly higher than that in control group (P<0.01). The PDGF level of intracerebral haemorrhagia group was increased remarkebly within 4 days. The expression of PDGF in platelets was also increased remarkebly as that in serum. The PDGF level was decreased remarkebly in the 8th day in intracerebral haemorrhagia group (P<0.05), and which was positively correlated with NIHSS appraise (r=0.62,P<0.01). The serum level of PDGF protein was positive associated with the value of hematoma (P<0.05).CONCLUSION: Increased PDGF level was found in the patients with intracerebral hemorrhage. The serum PDGF levels of patients with cerebral hemorrage may be used as a biomarker to reflect the degree of pathogenetic.

Key words: Platelet derived growth factor, Intracerebral haemorrhagia, Diagnosis