Histone demethylase JMJD1A and its biological functions

Abstract

Abstract: Histone demethylase JMJD1A (Jumonji domaincontaining protein 1A) regulates gene transcription by hydroxylation pathway, which demethylases mono- and di-methy H3K9 (H3K9me1/2). JMJD1A play roles in spermatogenesis, energy metabolism, regulation of stem cell as well as the initiation and progress of cancer. Here, we review the structure, catalytic mechanism, substrate specificity, biological function and inhibitor of JMJD1A.

Key words: JMJD1A, Histone demethylase, Gene transcriptional regulation

CLC Number:

R969.8

ZHAN Min, ZHOU Hong-hao. Histone demethylase JMJD1A and its biological functions[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(3): 325-330.

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