Influence of allicin on the function of organic anion transporting polypeptide 1B1

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2013, Vol. 18 ›› Issue (7): 749-753.

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Influence of allicin on the function of organic anion transporting polypeptide 1B1

YANG Guo-ying¹, MA Kai¹, WU Lan-xiang², ZHANG Wei³, ZHOU Hong-hao^2,3

¹Department of Urology, Taishan Medical University Affiliated Zouping People's Hospital, Binzhou 56200, Shangdong, China;
²Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China;
³Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha 400078, Hunan,China

Received:2012-07-16 Revised:2012-12-06 Online:2013-07-26 Published:2013-06-20

Abstract

Abstract: AIM: To investigate the effect of allicin on organic anion transporting polypeptide 1B1 (OATP1B1) activities.METHODS: Using human embryonic kidney 293 (HEK293) cells stably expressing OATP1B1, to observe the effect of allicin on OATP1B1-mediated uptake of [³H]estrone sulfate and pravastatin.RESULTS: Allicin can competitively inhibit the OATP1B1-mediated uptake of [³H]estrone sulfate and pravastatin, with the K_i values of (18.3±5.2)μmol/L and (15.4±6.8)μmol/L,repectively.CONCLUSION: These data indicate that modification of OATP1B1 transport activity by allicin is a mechanism for herb-drug interactions in human beings.

Key words: Allicin, OATP1B1, Her-drug interaction

CLC Number:

R969.2

YANG Guo-ying, MA Kai, WU Lan-xiang, ZHANG Wei, ZHOU Hong-hao. Influence of allicin on the function of organic anion transporting polypeptide 1B1[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(7): 749-753.

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Influence of allicin on the function of organic anion transporting polypeptide 1B1

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