The control research of escitalopram with or without eszopiclone on the treatment of generalized anxiety disorder with insomnia

Abstract

Abstract: AIM: To observe the efficacy and safety of escitalopram with or without eszopiclone on the treatment of generalized anxiety disorder with insomnia patients.METHODS: 100 patients who met the CCMD-3 criteria for generalized anxiety disorder with insomnia were randomly divided into the experimental group (n=52) and the control group (n=48). The experimental group were treated with escitalopram combining with eszopiclone, and the control group with escitalopram monotherapy. The trial lasted 8 weeks. The anxiety status and efficacy was evaluated with HAMA at the baseline,1st, 2nd, 4th, 6th and 8th weekend respectively, the insomnia status with SDRS, and the safety with TESS and laboratory examination.RESULTS: The HAMA scores of the experimental group and the control group declined significantly by the end of 1st week (P＜0.01)and the end of 2nd week (P＜0.01)respectively, and the reduction of HAMA scores of the experimental group was more significant than the control group at the end of 1st, 2nd, 4th and 6th weekend (P＜0.05), while there was no significant difference between the two groups at the end of 8th weekend (P>0.05). The SDRS scores of the experimental group declined significantly by the end of 1st week (P＜0.01), and the reduction of SDRS scores of the experimental group was more significant than the control group at the end of 1st, 2nd, and 4th weekend (P＜0.01). Side events happened more easily in the experimental group than in the control group such as headache, mouth pain, dry mouth, nausea and drowsiness(P＜0.05) .CONCLUSION: Escitalopram with eszopiclone on the treatment of generalized anxiety disorder with insomnia patients contribute to a rapid improvement in insomnia and anxiety, but the side effects are relatively obvious.

Key words: Generalized anxiety disorder, Insomnia, Escitalopram, Eszopiclone

CLC Number:

R749

LI Ya-ling, YE Jian-fei, LI Ting , LI Guo-rong. The control research of escitalopram with or without eszopiclone on the treatment of generalized anxiety disorder with insomnia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(1): 54-57.

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