Effect of CRRT on nitric oxide synthase and procalcitonin in systemic inflammatory response syndrome and sepsis patients

Abstract

Abstract: AIM: The purpose of this study is to evaluate the efficacy of the Continuous Renal Replacement Therapy (CRRT) on systemic inflammatory response syndrome (SIRS) and Sepsis and the influence on nitric oxide synthase (NOS) and procalcitonin (PCT), to provide new ideas on the CRRT of SIRS.METHODS: We collected the SIRS and Sepsis cases in Department of emergency ICU, internal medicine ICU and surgical ICU of our hospital, recorded changes (before CRRT, 12, 48, 72 h purification treatment), in vital signs, oxygenation index (PaO₂/FiO₂), blood biochemistry, blood routine, blood gas analysis and APACHE II score. NOS was detected by colorimetric method, and PCT was detected by immune chemiluminescence method.RESULTS: After 24, 48, 72 h of CRRT treatment, blood biochemical and blood indexes were significantly improved, and the values of NOS and PCT were all significantly lower than the values of treatment before. The difference was statistically significant (P<0.05).CONCLUSION: CRRT can improve the clinical symptoms of patients with SIRS/Sepsis by removing the damage factor of NOS and PCT.

Key words: CRRT, NOS, Procalcitonin, SIRS, Sepsi

CLC Number:

R631

ZENG Ai-ying, DAI Mu-sen, WANG Xiao-ping, CHEN Beng-dun, CHEN Min, CHEN Bing-xing, SUN Hong. Effect of CRRT on nitric oxide synthase and procalcitonin in systemic inflammatory response syndrome and sepsis patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(1): 62-66.

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