Advance in study on tacrolimus pharmacodynamics

Abstract

Abstract: Tacrolimus is a kind of calcineurin inhibitor, mainly suppressing the transcription of cytokines IL-2, IL-3, IL-4, IL-5, IFN-γ, TNF-α, GM-CSF and expression of IL-2, IL-17 receptor. In addition, tacrolimus shows remarkable immunosuppressive effects in the prevention and treatment of organ transplant rejection in clinical and animal experiments. Its major adverse reaction includes nephrotoxicity, neurotoxicity, hypertension, posttransplantation diabetes mellitus,gingival hyperplasia, and so on.

Key words: Tacrolimus, Pharmacodynamics, Cytokine, Rejection, Side effect

CLC Number:

YANG Meng, ZUO Xiao-cong,WANG Jiang-lin,CHEN Qing-Jie. Advance in study on tacrolimus pharmacodynamics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(1): 90-95.

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