Abstract: AIM: To compare the clinical efficacy and safety of influence of nifedipine sustained release tablets combined separately with enalapril maleate tablets and metoprolol tartrate tablets in the treatment of high-risk hypertension. METHODS: 130 cases diagnosed in high-risk hypertensive patients randomly divided into group A and group B, 65 cases in each group . Group A was given nifedipine sustained release tablets(20 mg, bid, p.o. ) and enalapril maleate tablets(10 mg, q.d., p.o. ), group B was given nifedipine sustained release tablets(20 mg, bid, p.o. ) and metoprolol tartrate tablets (100 mg, q.d., p.o.). The specific dosage adjustment of treatment based on patient compliance level. Two groups of patients were treated for 12 months. The changes of blood pressure and ADR were observed in 2 groups before and after treatment, and cardiovascular and cerebrovascular events out of the hospital.RESULTS: The total group A and group B efficiency rate , the blood pressure standard rate ,cardiovascular event rates were 90.48%, 80.95%, 14.28% and 87.50%, 78.13%, 15.62%, and showed no statistically significant difference (P>0.05). CONCLUSION: Nifedipine sustained release tablets combined with enalapril maleate tablets and nifedipine sustained release tablets combined with metoprolol tartrate tablets both can reach the treatment target,with safety, good tolerance,and high compliance.

Key words: nifedipine sustained release tablets, enalapril maleate tablets, metoprolol tartrate tablets, high-risk hypertension