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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2014, Vol. 19 ›› Issue (11): 1276-1280.

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131I doses calculated by thyroid weight-dosage relevant formula on therapy for Graves' hyperthyroidism with large goiter

ZHONG Ji-jun1, ZHOU Yong2, LIU Wei-ping1, GAO Qian-gang1, FANG Jie-mei1   

  1. 1 Department of Nuclear Medicine;
    2 Deparment of Medical Laboratory, Taizhou Central Hospital, Taizhou 318000, Zhejiang, China
  • Received:2014-05-14 Revised:2014-11-05 Online:2014-11-26 Published:2014-12-09

Abstract: AIM: To explore the efficacy of 131I doses calculated by thyroid weight-dosage relevant formula(131I dosage per g thyroid tissue: μCi/g=100+thyroid weight) on therapy for Graves' hyperthyroidism with large goiter. METHODS: Randomly distributed 105 Graves' hyperthyroidism with large goiter patients into 3 groups, Thyroid weigh was calculated by weight formula of SPECT. 131I Doses of the first group patients calculated by fixed dosage, that was 131I dosage per g thyroid tissue : μCi/g=150uCi; 131I dosage of the second group patients calculated by weight-excision formula, that was D=[d×8×m(g) ]÷[1.6×highest thyroid iodine uptake ×T1/2eff],d=m1÷m2×d0; d0 fixed to 55 Gy. 131I dosage of the third group patients calculated by thyroid weight-dosage relevant formula(131I dosage per g thyroid tissue : μCi/g=100+ thyroid weight). Comparing 131I Doses and frequency of 131I treatment for 3 groups patients when all 105 hyperthyroidism patients achieved normal thyroid function or hypothyroidism. RESULTS: ⑴ After the first 131I therapy, Thyroid function of The first group patients were 20 cases with hyperthyroidism, 10 cases with normal thyroid function and 5 with hypothyroidism; Thyroid function of The second group patients were 9, 20, 6 respectively; and the third group patients were 8, 18 , 9 respectively. ⑵ The doses of the first treatment of 131I were (20.9±6.0) mCi (the first group);25.9±11.8 (the second group) and 26.9±9.0 (the third group) respectively. ⑶ When all 105 hyperthyroidism patients achieved normal thyroid function or hypothyroidism, the mean 131I dose per patient were (31.5±16.0) mCi (the first group);30.1±18.9 (the second group) and 30.8±15.1 (the third group) respectively. CONCLUSION: 131I Doses calculated by thyroid weight-dosage relevant formula was a simple, feasible method. It can avoid the complex of weight-excision formula and could deserve of abroad clinical application.

Key words: 131I, large goiter, doses, Graves' hyperthyroidism, thyroid weight

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