Abstract: AIM: To evaluate the efficacy and safty of Chonglou Shenghua Tang for preventing lochiorrhagia after caesarean section (CS). METHODS: Using prospective and single blind methods, 584 women underwent caesarean section (CS) were divided into three groups randomly : Chonglou Shenghua Tang group(198 cases), Classical Shenghua Tang group (198 cases), placebo group (184 cases),and were administered by Chonglou Shenghua Tang, Classical Shenghua Tang and placebo 100 mL, per 12 hours 14 days after CS respectively. The following clinical parameter were collected and analyzed: (1) Uterine instauration: fundus height, the average drop speed of fundus;the sum of the three paths of uterus and uterine cavity hematocele, uterine incision healing by ultrasound monitoring 42 days after CS; (2)The lochia: the amount and duration of lochia rubra, duration of lochia. (3) The time of anus exhaust, adverse reaction. RESULTS: (1)Uterine instauration: On the height of fundus from the 2nd day to the fifth day after CS and the average drop speed of fundus, there were significant differences between groups, and Chonglou Shenghua Tang group was significantly better than the classical Shenghua Tang group and placebo group (P＜0.05). On the sum of the three paths of uterus, Chonglou Shenghua Tang group was significantly less than the Classical Shenghua Tang group group and placebo group(P＜0.05).Chonglou Shenghua Tang group was significantly better than the other two groups about uterine incision healing rate(P＜0.05). (2) On the amount and duration of lochia rubra, Chonglou Shenghua Tang group was significantly superior to the classical Shenghua Tang group and placebo group(P＜0.05).(3) Chonglou Shenghua Tang group was shorter than the control group significantly on the time of average anal exhaust(P＜0.05).4 cases with mild diarrhea at the beginning with the drug had been observed. CONCLUSION: It is efficacious and safe of using Chonglou Shenghua Tang to prevent lochiorrhagia after caesarean section.

Key words: Chonglou Shenghua Tang, lochiorrhagia, uterine instauration, caesarean section