Abstract: AIM: To assess the influence of morphine consumption on pancreatic cancer after neurolytic celiac block for cancer pain.METHODS: 98 patients were reviewed in 2007 June-2013 May, who suffered from advanced pancreatic cancer pain, morphine consumption≧90 mg/d, VAS≧5. The 46 patients therapied with morphine oral titration in control group for adjusting the final dose of morphine, the 52 cases of observation group were carried on neurolytic celiac plexus block(NCPB) with dehydrated ethanol via CT-guided, observed and compared before treatment, after 1, 2, 4, 6 months of two groups of patients taking morphine drug dosage, pain score(VAS) and side-effects, complications.RESULTS: The observation group were treated by NCPB in the period of 1, 2, 4, 6 months later, consumption of morphine and VAS were lower than before treatment (P＜0.01) and there was a gradually increasing trend in morphine drug dosage and VAS, but each time period were lower than those of in the control group(P＜0.01) for morphine dosage. All of the 98 patients after treatment, there were no serious complications, 1 cases of NCPB for patients after treatment occurred abstinence reaction in morphine withdrawal.CONCLUSION: Neurolytic celiac plexus block can effectively reduce advanced pancreatic cancer pain and morphine consumption. Individual dosage of morphine intake is requisite in cancer pain.

Key words: neurolytic celiac plexus block, morphine, pancreatic cancer