Association between BSG gene polymorphism and rheumatoid arthritis susceptibility

Abstract

Abstract: AIM: To investigate the association of BSG-10292T/A rs8259 polymorphisms with rheumatoid arthritis susceptibility in a Chinese Han population. METHODS: We performed a case-control analysis including a total of 196 cases and 249 healthy controls.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype the SNP.The expression of sCD147 in serum was detected. RESULTS:Our result indicated that there is significant difference in the allele frequencies between the RA cases and controls accompanied with a significant difference in sCD147.CONCLUSION: BSG-10292T/A polymorphism is associated with rheumatoid arthritis susceptibility in Chinese Han population.

Key words: rheumatoid arthritis (RA), BSG, CD147, polymorph

CLC Number:

R34
R596

GUO Ren, HUANG Pan-hao, LIU Zuo-liang. Association between BSG gene polymorphism and rheumatoid arthritis susceptibility[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(7): 780-784.

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