Progress on association between methylenetetrahydrofolate reductase genetic polymorphism and the risk of infertility

Abstract

Abstract: 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folic acid metabolic pathways. Currently data reported that single nucleotide polymorphisms may decrease the activity of the enzyme. The enzyme keeped the normal levels of homocysteine in body and involved in the synthesis of DNA. MTHFR gene polymorphism was found to be probably related to male sterility and recurrent miscarriage of childbearing women, leading to high homocysteine levels and the disorder of DNA synthesis and low methylation reaction. All of these make the folate metabolism disorder. This paper discusses the association between genetic factor (gene polymorphism of 5,10-methylenetetrahydrofolate reductase) and male infertility and recurrent miscarriage of childbearing women.

Key words: 5,10-methylenetetrahydrofolate reductase, gene polymorphism, infertility

CLC Number:

R711

LIU Dan-qi, SHENG Yang-hao, WANG Ping, YAN Xiao-min, ZHOU Bo-ting. Progress on association between methylenetetrahydrofolate reductase genetic polymorphism and the risk of infertility[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(2): 235-240.

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