The tissue penetration and pharmacodynamics of linezolid in the infected tissues

Abstract

Abstract: Linezolid has strong antibacterial activities for G⁺ infection and perfect pharmacokinetics and tissue penetration, more than 50% plasma (or serum) concentration of linezolid was detected in the infected tissues. Different PK/PD parameters was found according to different pathogens and different infected tissues. The MIC value of linezolid for susceptible bacteria was 0.5-2 μg/mL.The post-antibiotic effect of linezolid was found in some specific bacteria. Linezolid can be used as the most solid barriers in the treatment of multiresistant G⁺ infection. The tissue penetration and pharmacodynamics characteristics of linezolid in the treatment of G⁺ infection is summarized, which can help healthy providers decide how to use linezolid in the treament of G⁺ infections.

Key words: linezolid, tissue penetration, MIC, post-antibiotic effect, PK/PD parameters

CLC Number:

R969

LI Chun-xing, FU Qiang, ZHU Zhu. The tissue penetration and pharmacodynamics of linezolid in the infected tissues[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(3): 349-355.

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