Alternate dosing of ezetimibe and colestipol on regulating lipid metabolism in hyperlipidemia rats

Abstract

Abstract:

AIM: To explore alternate dosing of ezetimibe and colestipol on regulating for lipid metabolism in hyperlipidemia rats. METHODS:Fifty rats of clean grade, half male and female were modeling through feeding high fat diet; the rats were randomly divided into normal group, model group, and experimental groups (including ezetimibe group, colestipol group, ezetimibe+colestipol group); experimental groups received gavage administration, while the normal group and model group were given normal saline for 8 weeks; TG, TC, HDL-C, LDL-C and ACC, FAS, HMGR, CPT-I expression of mRNA in serum were thereafter detected. RESULTS: The levels of TC, TG, LDL-C and AAC, FAS, HMGR mRNA in serum were decreased, and levels of ezetimibe+colestipol group were significantly lower than those of single drug group (P<0.05). CONCLUSION: Alternate dosing of ezetimibe and colestipol was better than single medication in regulating lipid metabolism in hyperlipidemia rats, but the effect on human body still needs further clinical validation.

Key words: ezetimibe, colestipol, hyperlipidemia

CLC Number:

R965.2

YANG Yi, GUAN Qiaobing, GUO Li, LI Wenyan, ZHANG Hui, HAN Chenyang. Alternate dosing of ezetimibe and colestipol on regulating lipid metabolism in hyperlipidemia rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(10): 1112-1116.

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