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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2017, Vol. 22 ›› Issue (11): 1274-1277.

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Effects of esmolol on hemodynamics and inflammatory response in patients with septic shock

CHEN Caojie 1, XU Chi 2   

  1. 1 Emergency Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China; 2 Emergency Department, Wuxi People's Hospital, Wuxi 214043, Jiangsu, China
  • Received:2017-06-26 Revised:2017-08-22 Online:2017-11-26 Published:2017-12-11

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Abstract:

 AIM: To investigate the effects of esmolol on hemodynamics and inflammatory response in patients with septic shock. METHODS: Ninety two patients with septic shock were divided into observation group and control group, with 46 cases in each group. The control group received milrinone treatment while the observation group received esmolol combined milrinone. Heart rate (HR), mean arterial pressure (MAP), cardiac index (CI), stroke volume index (SVI) and lactic acid (Lac) were compared between the two groups before and after treatment. Heart function changes were detected by echocardiography, including left ventricular ejection fraction (LVEF), mitral valve peak diastolic flow velocity (E)/mitral valve peak diastolic flow velocity (A). The acute physiology and chronic health evaluation (APACHE-II) and sequential organ failure assessment (SOFA) were used to assess the changes in the patient's condition. The changes of inflammatory indexes (PCT, CRP, and WBC) before and after treatment were compared between the two groups. RESULTS:After treatment, the levels of CI and SVI in the two groups were significantly increased while Lac decreased significantly (P<0.05); CI, SVI and the level of E/A in the observation group were significantly higher than those in the control group while Lac was significantly lower than that in the control group (P<0.05). The scores of APACHE II and SOFA in the two groups were significantly lower than those before treatment (P<0.05); after treatment, the scores of APACHE II and SOFA in the observation group were significantly lower than those in the control group (P<0.05); the levels of PCT, CRP and WBC in the two groups were significantly lower than those before treatment (P<0.05). After treatment, the PCT, CRP and WBC in the observation group were significantly lower than those in the control group (P<0.05). CONCLUSION: Esmolol can significantly reduce the inflammatory response and improve the hemodynamic level in patients with septic shock.

Key words: esmolol, septic shock, inflammatory reaction, hemodynamics

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