Research advance of central σ-2 receptor on the pathogenesis and therapeutics of neuropsychiatric diseases

Abstract

Abstract:

Recent studies indicated that the central σ-2 receptor may play an important role in the pathogenesis and therapeutics of neuropsychiatric diseases. In the recent years, its neurobiological functions have attracted great attention with the emergence of available new selective σ-2 receptor ligands. Several new studies suggest that σ-2 receptor is a part of PGRMC1, shading new light on and direction for the function investigation of σ-2 receptor. Thus, in this review, the physiological functions of σ-2 receptor in the central nervous system, and the involvement of σ-2 receptor in various neuropsychiatric diseases and related treatment are discussed.

Key words: σ-2 receptor, PGRMC1, neuropsychiatric diseases

CLC Number:

R741
R749

WU Yanqin, JIANG Pei, TAN Qinyou, XU Ping, LI Huande, CAI Hualin. Research advance of central σ-2 receptor on the pathogenesis and therapeutics of neuropsychiatric diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 210-214.

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