Abstract:

AIM: To evaluate the clinical efficacy of fluorouracil coated with interferon injection combined with liquid nitrogen cryotherapy in the treatment of verruca plantaris and influence on immune function in patients.  METHODS: 78 cases of verruca plantaris were divided into two groups, each group of 39 cases. In the control group, the liquid nitrogen was used as the control group, and on the basis of the control group, the observation group was given intramuscular interferon. Changes of skin lesions in the two groups were observed. Changes of T lymphocyte levels before and after treatment were compared between the two groups. DLQL method was used to assess the quality of life of patients. RESULTS: The curative effect of the observation group was significantly better than that of the control group. The difference was statistically significant (Z=2.312,P<0.05). CD3, CD4, CD4/CD8 of observation group were significantly increased after treatment (P<0.05). After treatment, the CD3, CD4 and CD4/CD8 in the observation group were significantly higher than those in the control group. The difference was statistically significant (P<0.05). After treatment, the skin lesion score and DLQL score of the observation group were significantly lower (P<0.05) than that of the control group. After treatment, the skin lesion score and DLQL score of the observation group were significantly lower than that of the control group. The difference was statistically significant (P<0.05). CONCLUSION: The therapeutic effect of fluorouracil coated with interferon injection combined with liquid nitrogen cryotherapy in the treatment of verruca plantaris is effective, and can significantly improve the immune function of patients.

Key words: fluorouracil, interferon, cryotherapy, verruca plantaris, immune function