Effects of precise anesthesia on perioperative cellular immune function in patients undergoing robot-assisted laparoscopic radical prostatectomy

doi:10.12092/j.issn.1009-2501.2018.02.011

Abstract

Abstract:

AIM: To evaluate the effects of precise anesthesia on perioperative cellular immune function in patients undergoing robot-assisted laparoscopic radical prostatectomy. METHODS: Fifty-six patients who underwent robot-assisted laparoscopic radical prostatectomy were randomly allocated into control group(A, n=28) and experiment group(B, n=28). In group A, propofol was infused to achieve the BIS value of 45-55, and the muscle relaxation was monitored to conduct closed-loop infusion of cisatracurium, liquid input were monitored and managed by Vigileo. In group B,the depth of anesthetic with the patients' vital signs according to anesthetists' experience was regulated. Venus blood were sampled respectively before anesthesia induction(T0), after induction of anesthesia before surgery(T1), 1 h after anesthesia(T2), 2 h(T3), 24 h (T4),72 h after operation (T5). The percentages of T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+,FoxP3-Treg ratio) and NK ratio were detected by flow cytometry. RESULTS: Compared with group B,CD4+ at T1,T2,T4 and T5 were higher in group A,NK cells at T2 were higher in group A (P<0.05). Compared with T0,CD4+ and CD4+/CD8+ increased at T1 in group A, CD4+ and NK cells were decreased at T1 in group B (P<0.05); CD3+,CD4+,CD8+,CD4+/CD8+ and NK cells were significantly decreased at T2 in group B (P<0.05); CD3+,CD4+ decreased significantly at T3 in both group A and group B and CD4+/CD8+ decreased in group B (P<0.05); CD4+ increased in group A and the level of Treg both in A and B groups were decreased significantly at T5 (P<0.05). CONCLUSION: Precise anesthesia can reduce the inhibitory effect of general anesthesia on cellular immune function in patients undergoing robot-assisted laparoscopic radical prostatectomy.

Key words: robot, laparoscopic, prostatic cancer, cellular immune function

CLC Number:

R614

WANG Ting, CHEN Ke, ZHOU Changping, WANG Yiqiao, LU Xianfu, LI Yuanhai. Effects of precise anesthesia on perioperative cellular immune function in patients undergoing robot-assisted laparoscopic radical prostatectomy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(2): 175-179.

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