Abstract:

 AIM: To explore the curative effect and security of ginkgo-dipyridamolum injection combined hyperbaric oxygen and acupuncture in treatment of patients with sudden deafness, and to provide a reference for clinical treatment. METHODS: Ninety-four patients with sudden deafness were divided into the control group (47 cases) and observation group (47 cases) according to random number table method. The two groups were given conventional western medicine treatment, the control group was given hyperbaric oxygen and acupuncture, while the observation group was given 20 mL ginkgo-dipyridamolum injection by intravenous drip on the basis of control group treatment. After 2 weeks treatment the clinical curative effect and safety were observed, and the blood rheology indexes, coagulation function, lipid peroxide (LPO) superoxide dismutase (SOD), thromboxane B2 (TXB2) and vascular endothelial cadherin (VE-cadherin) were compared. RESULTS:The total effective rate was 98.87% in the observing group, and 82.98% in the control group, there was no statistically significant difference of rank and inspection (P>0.05). The pure tone hearing threshold value in the observation group was lower than the control group, the difference was statistically significant (P<0.05). The whole blood viscosity, plasma viscosity, erythrocyte deposited and erythrocyte aggregation index in the observation group were significantly lower than the control group, the differences were statistically significant (P<0.05). The thrombin time in the observation group was higher than the control group, and the fibrinogen, blood coagulation factor Ⅰ and platelet factor were lower than the control group, the differences were statistically significant (P<0.05). The levels LPO, TXB2 and VE-cadherin of the observation group were lower than the control group, and the SOD level was higher than that in the control group, the differences were statistically significant (P<0.05). The mainly adverse reactions were headache, gastrointestinal discomfort, palpitation, itchy skin in two groups. The incidences of adverse drug reactions were 21.28% and 17.02% in the observation group and control group,respectively.There was no statistically significant difference (P>0.05). CONCLUSION:Ginkgo-dipyridamolum injection combined hyperbaric oxygen and acupuncture in treatment of patients with sudden deafness have better clinical curative effect, can reduce the pure tone hearing threshold value to restore hearing, improve blood rheology indexes and blood coagulation function, repair blood vessels endothelial injury, and have better security. They are worthy of clinical popularization and application.

Key words: sudden deafness, ginkgo-dipyridamolum, hyperbaric oxygen, acupuncture, blood rheology, blood coagulation function