Effect of Xingnaojing injection on the expression of hypoxia-inducible factor-1α in patients with acute cerebral infarction

Abstract

Abstract:

AIM: To investigate the effect of Xingnaojing injection on ischemic stroke patients and its impact on the level of hypoxia-inducible factor-1α(HIF-lα). METHODS: Sixty-eight cases of ischemic stroke patients were randomly divided into treatment group (n=35) and control group (n=33). Both groups were given regular treatment for 10 days. Patients of treatment group were given additional Xingnaojing injection. Evaluation of National Institutes of Health Stroke Scale (NIHSS) score and detection of serum HIF-lα level were performed before treatment, 3 days and 10 days after the treatment. RESULTS: After treatment, NIHSS scores of treatment group on day 3 and day 10 and those of control group on day 10 were statistically lower than those before treatment（P<0.05), the treatment group decreased more significantly (P<0.05). Serum HIF-lα level of both groups on day 3 and day 10 were statistically lower as compared to those before treatment（P<0.05）, the control group decreased more significantly（P<0.05）. Pearson correlation analysis showed that the level of HIF-lα was positively correlated with the decreasing of NIHSS(P<0.05). CONCLUSION: Xingnaojing injection can protect and improve ischemic brain tissues by promoting serum HIF-lα level.

Key words: Xingnaojing injection, ischemic stroke, hypoxia-inducible factor-1α

CLC Number:

R743.3

CHEN Yanbin, DENG Shanshan. Effect of Xingnaojing injection on the expression of hypoxia-inducible factor-1α in patients with acute cerebral infarction[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(7): 821-824.

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