Effects of Jiawei Zengye decoction on diphenoxylate-induced constipation in mice

Abstract

Abstract:

AIM: To study the effect of dendrobii officmalis caulis (DOC) and/or atractylodismacrocephalaerhizoma (AMR) based on Zengyedecoction (ZYD), including scrophulariaeradix, rehmanniaeradix, ophiopogonisradix on diphenoxylate-induced constipation in mice. METHODS: Diphenoxylate was used to establish the mouse model of constipation, the decoction of DOC+AMR+ZYD, AMR+ZYD and ZYD, the dissolving liquid of Maren capsule (MRC) were prepared, after the gavage administration of them respectively, the defecation, small intestine propulsion and serum SOD activity in constipated mice were detected.RESULTS:The efficacy of promoting defecation and small intestine propulsion by DOC+AMR+ZYD and AMR+ZYD was better than that of ZYD and MRC; DOC+AMR+ZYD significantly increased serum SOD activity in constipated mice and the efficacywas superior to ZYD and MRC. CONCLUSION:DOC+AMR and AMR enhanced ZYD efficacy on diphenoxylate-induced constipation in mice,DOC+AMR+ZYD elevated the constipated mice serum SOD activity.

Key words: dendrobii officmalis caulis, Zengyedecoction, constipation, gastrointestinal motility

CLC Number:

R965.2

ZHAO Tianwen, TANG Hanxiao, HUANG Wenjing, BAO Yishu, CHEN Congcong, CHEN Dongsheng, SHENG Yunjie, ZHANG Yongsheng. Effects of Jiawei Zengye decoction on diphenoxylate-induced constipation in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(8): 866-869.

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