Abstract:

 AIM: To analyze the effect of gexiazhuyu decoction on blood coagulable status and life quality of patients with liver cancer, so as to provide evidence for its clinical application.  METHODS: 105 patients with liver cancer were divided into two groups: the control group (n=52) and the observation group (n=53). All the patients were given surgery,while the patients of the observation group were given gexiazhuyu decoction at the same time. A follow-up of three to five years was completed, and the recurrence rate, survival rate and life quality score of patients were record. Peripheral blood was extracted to detect liver function, hemorheology, vascular endothelial growth factor (VEGF) and intercellular adhesive molecular-1 (ICAM-1). RESULTS: There was no significant difference in postoperative survival curve and survival rate between groups (P>0.05), while the recurrence rate of the observation group in five years after treatment was lower than that of the control group, the QOL-LC score and self assessment score of the observation group were both higher than those of the control group, and the difference had statistical significance (P<0.05). There was no significant difference in liver function indexes and blood clotting indexes between groups before treatment (P>0.05). After treatment, the aspartate amino transferase (AST), alanine aminotransferase (ALT), whole blood high shear viscosity, low shear rates, red cell assembling index, plasma fibrinogen (Fb), VEGF and ICAM-1 of patients were decreased, and the levels of the observation group were lower; the plasma prothrombin time of patients was increased, and the levels of the observation group was higher; all the difference between groups had statistical significance (P<0.05). CONCLUSION: Gexiazhuyu decoction can remit the blood coagulable states, which is benefit to prevent relapse and improve life quality.

Key words: gexiazhuyu decoction, TCM syndrome types, primary hepatic carcinoma, life quality,  , blood coagulable status