Effects of oxycodone hydrochloride combined with dexmedetomidine postoperative analgesia on sleep quality of patients with gastrointestinal tumors

doi:10.12092/j.issn.1009-2501.2018.02.009

Abstract

Abstract:

AIM: To evaluate the effects of hydrochloride oxycodone combined with dexmedetomidine postoperative analgesia on sleep quality of patients with gastrointestinal tumors. METHODS: Sixty ASA Ⅰ or Ⅱ patients aged 49-74 year with BMI of 17-24 kg/m2 undergoing laparoscopic resection of gastrointestinal tumors were randomly divided into 3 groups (n=20 in each group): group Ⅰ oxycodone (group O) , dexmedetomidine 0.05 μg·kg^-1·h^-1 combined with oxycodone group (group D1), dexmedetomidine 0.1 μg·kg^-1·h^-1 combined with oxycodone group (group D2). In O, D1, and D2 groups, the PCIA solution contained oxycodone 50 mg, oxycodone 50 mg plus dexmedetomidine 0.05 μg·kg^-1·h^-1, and oxycodone 50 mg plus dexmedetomidine 0.1 μg·kg^-1·h^-1 in 100 mL of 0.9% normal saline, respectively. The PCIA pump was set up to deliver a 0.5 mL bolus dose with a 15-min lockout interval and background infusion at 2 mL/h. VAS score was maintained ≤4. Polysomnography measures were performed the night before surgery (T0), the first night after surgery (T1), and the second night after surgery (T2), and recorded the sleep efficiency index (SEI), arousal index (AI), the percent of rapid eye-movement(REM). Patients' satisfaction and the occurrence of adverse reactions such as hypotension, bradycardia, somnolence, dizziness, vomiting were also recorded. RESULTS: Compared with T0, SEI were significantly decreased and AI were significantly increased in T1 of three groups and T2 of group O (P<0.05); Compared with group O, SEI were significantly increased and AI were significantly decreased in group D1 and D2 (P<0.05), the patients' satisfaction and the occurrence of hypotension were significantly increased, the occurrence of vomiting was significantly decreased (P<0.05); Compared with group D1, the occurrence of hypotension, bradycardia, somnolence was significantly increased in group D2 (P<0.05). CONCLUSION: Postoperative analgesia with small dose of dexmedetomidine combined with oxycodone hydrochloride can significantly improve the sleep quality of patients with gastrointestinal tumors, with fewer occurrence of hypotension and better patients' satisfaction.

Key words: dexmedetomidine, hydrochloride oxycodone, sleep quality, analgesia

CLC Number:

R614

WANG Jun, JIANG Zongming, ZHENG Jungang, CAO Gang, HUANG Changshun, LU Zihui, JI Yiqin. Effects of oxycodone hydrochloride combined with dexmedetomidine postoperative analgesia on sleep quality of patients with gastrointestinal tumors[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(2): 165-169.

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