Effects of early intervention of massage combined with probiotics on neonatal jaundice of later period preterm infants

doi:10.12092/j.issn.1009-2501.2018.06.013

Abstract

Abstract:

AIM: To investigate the effects of early intervention of massage combined with probiotics on neonatal jaundice of later period preterm infants. METHODS: A total of 242 later period preterm infants in neonatology department were included in this study.The infants were randomly allocated to massage group and control group. After excluding 182 cases, thirty cases in each group completed the research. Both the massage group and the control group were given bifid triple viable from first feeding time to the fourth day after birth. The massage group received massage therapy for four days from the first day postnatal while the control group received routine care. The first feeding time, the first defecation time,the daily stool frequency and the transcutaneous bilirubin level (for four days from the first day postnatal) were recorded, and the serum bilirubin level on the fourth day postnatal was also detected to investigate whether they have complications, such as ventosity, diarrhea, vomiting, infection and other complications. RESULTS: Compared with the control group, the number of defecation times of the infants in the massage group was more than that of the control group on day 2-4 after birth (P<0.05); the transcutaneous bilirubin level in the massage group was significantly lower than the control group on day 3-4 after birth (P<0.05); the serum bilirubin level of the infants in the massage group was significantly lower than that of the control group on the fourth day after birth (P<0.05). There were no complications such as ventosity, diarrhea, vomiting and infection in the two groups. CONCLUSION: Early intervention of massage combined with probiotics can significantly reduce the level of bilirubin on day 4 after birth in later period preterm infants.

Key words: neonatal jaundice, massage, probiotics, transcutaneous bilirubin

CLC Number:

R722.11

YU Jinjing, ZHANG Yanping, PAN Jiahua. Effects of early intervention of massage combined with probiotics on neonatal jaundice of later period preterm infants[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(6): 678-681.

References

［1］Scrafford CG,Mullany LC,Katz J,et al.Incidence of and risk factors for neonatal jaundice among newborns in southern Nepal［J］.Trop Med Int Health,2013,18(11):1317-1328.
［2］Schwartz HP,Haberman BE,Ruddy RM.Hyperbilirubinemia:current guidelines and emerging therapies［J］.Pediatric Emerg Care,2011,27(9):884-889.
［3］Eghbalian F, Rafienezhad H, Farmal J. The lowering of bilirubin levels in patients with neonatal jaundice using massage therapy: A randomized, doubleblind clinical trial［J］. Infant Behav Dev, 2017, 49 （2017）:31-36.
［4］李寿军, 潘祥龙, 卜晓敏, 等. 新生儿黄疸治疗中应用蓝光照射联合早期抚触的临床效果［J］. 淮海医药, 2018, 36(1): 7-9.
［5］温美莲, 陈浩. 抚触护理联合熊去氧胆酸治疗新生儿胆汁淤积性黄疸的临床观察［J］. 中国医学创新, 2017, 14(17): 79-82.
［6］Liu W, Liu H, Wang T, et al. Therapeutic effects of probiotics on neonatal jaundice［J］. Pak J Med Sci，2015, 31(5): 1172-1175.
［7］侯玮玮, 朱玲玲. 益生菌联合蓝光治疗新生儿黄疸的疗效及预后分析［J］. 中国妇幼保健, 2017, 32(22): 5771-5773.
［8］逯军, 凌瑶君. 蓝光联合益生菌口服治疗早产儿黄疸临床观察［J］. 山东医药, 2017, 57(9): 77-79.
［9］王玲丽.早期抚触护理在新生儿生理性黄疸治疗中的效果观察［J］.临床医学研究与实践,2017,2(14):157-158.
［10］Mcgillivray A,Polverino J,Badawi N,et al.Prospective surveillance of extreme neonatal hyperbilirubinemia in Australia［J］.J Pediatr,2016,168:82-87.e3.
［11］Elhawary IM, Abdel Ghany EAG, Aboelhamed WA, et al. Incidence and risk factors of postphototherapy neonatal rebound hyperbilirubinemia［J］. World J Pediatr，2018, Feb 20.
［12］Sharif MR, Kashani HH, Ardakani AT, et al. The effect of a yeast probiotic on acute diarrhea in children［J］. Probiotics Antimicrob Proteins, 2016, 8(4): 211-214.
［13］Chen Z, Zhang L, Zeng L, et al. Probiotics supplementation therapy for pathological neonatal jaundice: a systematic review and metaanalysis［J］. Front Pharmacol, 2017, 8:432.
［14］余金晶.莫沙必利联合不同益生菌对早产儿胃肠功能及早期生长发育的影响［D］.安徽医科大学,2014.
［15］Caffarelli C, Santamaria F, Vottero A, et al. Progress in pediatrics in 2013: choices in allergology, endocrinology, gastroenterology, hypertension, infectious diseases, neonatology, neurology, nutrition and respiratory tract illnesses［J］. Ital J Pediatr, 2014, 40:62.
［16］Dalili H,Sheikhi S,Shariat M,et al.Effects of baby massage on neonatal jaundice in healthy Iranian infants:A pilot study［J］.Infant Behav Dev,2016,42(2016):22-26.
［17］Lin CH, Yang HC, Cheng CS, et al. Effects of infant massage on jaundiced neonates undergoing phototherapy［J］. Ital J Pediatr, 2015, 41:94.

[1]	ZHANG Qiang, ZHENG Huajun, LI Quan. Research progress on the treatment of autism spectrum disorders based on gut microbiota intervention [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(4): 475-480.
[2]	FANG Qing, OU-YANG Dongsheng. Trimethylamine N-oxide and inflammatory disease [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(3): 318-326.
[3]	LI Yongpei, ZHU Yunxia, HUANG Ting. Effects of medicated bath hydrotherapy combined with Yinzhihuang oral liquid on neonatal jaundice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(9): 1047-1051.
[4]	ZENG Chuanli, HU Airong, HU Yaoren, YUAN Gang, ZHU Dedong, SHI Xiaojun. Clinical effect of entecavir combined with probiotics on treatment of patients with hepatitis B cirrhosis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(7): 796-801.
[5]	DENG Zuyue, HUANG Junjun. Healing effect of Xianling Gubao plus probiotics on osteoporotic fracture rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(10): 1126-1131.