Effects of nicotinamide ribose on adolescent depression rats after neonatal maternal deprivation

doi:10.12092/j.issn.1009-2501.2018.09.008

Abstract

Abstract:

AIM: To explore the effects of nicotinamide ribose (NR) on adolescent depression rats after neonatal maternal deprivation (NMD). METHODS: NMD was performed as mother-infant separation from postnatal day (PND) 2 to PND 21 for 3 hours (9∶00-12∶00 AM) each day. At PND 21, isolated rats were divided into three groups randomly: isolated depression group (saline, n=6), sertraline group (40 mg·kg^-1·d^-1, n=7) and NR group (400 mg·kg^-1·d^-1, n=7), which were treated for 21 days and once daily. The normal control rats were treated with saline (n=6). From PND 42 on, forced swimming test (FST), sucrose preference test (SPT), open field test (OFT) and novel object recognition test (NORT) were detected. Then the contents of 5-HT, DA, NE and NAD⁺ in the hippocampus and prefrontal cortex (PFC) were detected by respective ELISA kits. RESULTS: Exposed to NMD, the body weight increased slightly. NR treatment had no improvement on body weight compared with normal control group. However, NR treatment increased the sucrose preference ratio, rearing times, discrimination ratio (DR) and discrimination index (DI). Also NR treatment decreased the immobility time in FST. The results of ELISA showed NR treatment increased the contents of DA, NE, NAD⁺ in the frontal cortex and the contents of DA, NAD⁺in hippocampus. CONCLUSION: NR improved the depressive behaviors through the increase of neurotransmitters contents and NAD⁺ . It maybe provide experimental basis for screening of anti-depressants.

Key words: nicotinamide ribose (NR), depression, neonatal maternal deprivation (NMD), adolescent, rats

CLC Number:

WANG Rouxin, FANG Zekang, YAO Siqi, XUE Yingying, ZHAO Yeying, YE Yilu. Effects of nicotinamide ribose on adolescent depression rats after neonatal maternal deprivation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(9): 1015-1021.

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