Effects of Qingchang zhili soup and moxibustion on ulcerative colitis and inflammatory factors

doi:10.12092/j.issn.1009-2501.2019.02.013

Abstract

Abstract:

AIM:To expolre the effect of Qingchang zhili soup and moxibustion on ulcerative colitis and inflammatory factors. METHODS:From July 2016 to May 2017,a total of 110 patients with ulcerative colitis in our hospital were randomly divided into combined treatment group(55 cases) and control group(55 cases),the control group was treated with methalazine,0.8 g,3 times/d, and the combined treatment group received extra Qingchang zhili soup,100 mL,1 time/d and moxibustion,30 min/d,the course of treatment were 2 weeks.The curative effect,TCM syndrome scoring,the Improve Mayo activity index,Baron endoscopy grading,inflammatory cytokines including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8) before and after treatment were compared,the adverse reactions during the treatment were also recorded and compared. RESULTS:The total effective rate of the combined treatment group was significantly higher than that of the control group（χ2=6.111，P=0.013）.There was no significant difference in TCM syndrome score between the two groups before treatment（P＞0.05）,both groups decreased significantly after treatment（P＜0.05）,the syndrome score of the combined treatment group was significantly lower than control group（P＜0.05）.There was no significant difference in Improve Mayo activity index and Baron endoscopy grading between the two groups before treatment（P＞0.05）,they were significantly reduced in both groups after treatment（P＜0.05）,the scores in combined treatment group were significantly lower than those of the control group（t=-17.407，-13.671；P=0.000，P=0.000）.There was no significant difference in levels of TNF-α, IL-6, IL-8 between the two groups before treatment（P＞0.05）, they were significantly reduced in both groups after treatment（P＜0.05）,the levels in combined treatment group were significantly lower than the control group（t=-19.611，-7.391，-5.404；P=0.000，P=0.000，P=0.000）.There was no significant difference in incidence of adverse reactions between the two groups（7.27% vs.14.55%；χ2=0.842，P=0.359）.CONCLUSION:The efficacy of Qingchang zhili soup and moxibustion in the treatment of ulcerative colitis is positive;it can better control the intestinal mucosal inflammation and inflammatory factor levels.

Key words: Qingchang zhili soup, moxibustion, ulcerative colitis, inflammatory factor

CLC Number:

ZHENG Weiwei, WANG Jiajia. Effects of Qingchang zhili soup and moxibustion on ulcerative colitis and inflammatory factors[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(2): 198-204.

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