Effects of vertebroplasty combined with Bushen Buxue Recipe on postoperative inflammatory factors and re-fracture in patients with vertebral fracture

doi:10.12092/j.issn.1009-2501.2019.02.015

Abstract

Abstract:

AIM: To study the effect of vertebralplasty combined with Bushen Buxue Recipe on postoperative inflammatory factors and re-fracture in patients with vertebral fracture. METHODS: From April 2013 to May 2016, 96 patients with vertebral fracture treated with vertebroplasty were selected and randomly divided into study group (combined with the Chinese herbal compound of tonifying kidney and blood) and control group, 48 cases in each group. The clinical efficacy was evaluated by comparing the levels of TNF-α, IL-1, IL-6, lumbar vertebrae and thoracic vertebrae bone mineral density, re-fracture rate, pain and swelling and so on after treatment in two groups. RESULTS:After treatment, the levels of TNF-α, IL-1 and IL-6 in the study group were significantly lower than the control group, the difference was significant (P<0.01); the pain, swelling and Barthel index (BI) were significantly better than the control group, the difference was statistically significant (P<0.01); lumbar vertebrae bone density and thoracic vertebrae bone density were significantly higher than the control group, the difference was statistically significant (P<0.05); the incidence of re-fracture was significantly higher in the study group during the 12-month follow-up period. The lower than the control group, the total effective rate of treatment was significantly higher than the control group, the difference was statistically significant (P<0.05). CONCLUSION:Vertebral fracture patients treated with vertebroplasty combined with Chinese herbal compound of tonifying kidney and blood can effectively inhibit postoperative inflammatory response, relieve pain and swelling, improve bone mineral density, reduce the risk of fracture and improve the quality of life and efficacy.

Key words: vertebral fractures, vertebroplasty, Bushen Buxue Recipe, inflammatory factors, re-fracture

CLC Number:

R285
R683

SHI Tieying, ZHOU Qihao, FENG Li, ZHOU Dongming, HOU Zhenhai. Effects of vertebroplasty combined with Bushen Buxue Recipe on postoperative inflammatory factors and re-fracture in patients with vertebral fracture[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(2): 212-217.

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