Research progress in the mechanism of BRAF inhibitor resistance in melanoma

doi:10.12092/j.issn.1009-2501.2020.05.015

Abstract

Abstract: Melanoma is a malignant tumor of melanocyte origin, and BRAF mutations occur in about 50% of melanoma patients clinically. BRAF inhibitors can target mutated BRAF sites, thus rapidly inhibiting the proliferation and promoting apoptosis of tumor cells. However, the subsequent rapid occurrence of drug resistance events seriously restricted the continuous use of such drugs, so it is of great importance to explore the mechanism of BRAF inhibitors resistance. This paper introduces the research progress of BRAF inhibitor resistance in melanoma in recent years, in order to provide some references for the follow-up research and clinical application.

Key words: melanoma, BRAF inhibitors, resistance mechanism, treatment strategies

CLC Number:

WANG Cheng, MA Pengcheng, SUN Jianfang, LI Hongyang. Research progress in the mechanism of BRAF inhibitor resistance in melanoma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(5): 576-583.

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