Effect of gender on the efficacy of fospropofol disodium in inhibiting the reaction of gastroscopy insertion

doi:10.12092/j.issn.1009-2501.2026.07.006

Abstract

Abstract:

AIM: To evaluate the effect of gender on the efficacy of fospropofol disodium in inhibiting the reaction of gastroscopy insertion. METHODS: This study was a prospective trial. Patients scheduled for painless gastroscopy, aged 18 to 64 years, with a BMI of 18 to 25 kg/m², and ASA physical status classification Ⅰ or Ⅱ, were selected and divided into three groups randomly: male group (M group), female group (F group), and gender-unrestricted group (C group). A dose of 0.2 mg/kg of nalbuphine was intravenously injected, followed by fospropofol disodium 1 minutes later. When the modified observer's assessment of alertness and sedation (MOAA/S) ≤3, gastroscopy was performed by an experienced senior physician. According to the improved Dixon sequential method, the dose of fospropofol disodium for the first patient was set at 10 mg/kg. If the patient showed any reaction affected the procedure during the insertion of the endoscope, it was judged as a positive reaction, and the dose for the next patient was increased by 1 mg/kg; otherwise, it was decreased by 1 mg/kg. The trial was terminated when there were 7 positive and negative reaction crossover points, and adverse reactions were observed. The dose-response relationship was calculated by probit regression analysis method. RESULTS: The ED₅₀ of fospropofol disodium in group M was 14.713 mg/kg (95% CI 14.044-14.988 mg/kg), ED₉₅ was 16.854 mg/kg (95% CI 14.229-17.339 mg/kg). In group F, ED₅₀ was 12.938 mg/kg (95% CI 12.072-13.363 mg /kg), and ED₉₅ was 15.289 mg/kg (95% CI 12.265-16.293 mg /kg). Compared with group M, the ED₅₀ of group F was decreased (P<0.05). The ED₅₀ of fospropofol disodium in group C was 13.915 mg/kg (95%CI 13.110-13.977 mg/kg), and ED₉₅ was 15.545 mg/kg (95%CI 13.311-15.675 mg/kg). Abnormal sensations occurred in 15 patients (16%), and respiratory depression occurred in 2 cases (2%). CONCLUSION: Gender factors influence the efficacy of sodium phosphopropofol in suppressing the response to endoscope insertion, with higher efficacy observed in females than that in males.

Key words: gender factors, gastroscopy, fospropofol disodium, nalbuphine, dose-response relationship

CLC Number:

R614

Yi ZHANG, Jie FANG, Shu ZHAO, Jingli YUAN, Xuejun REN. Effect of gender on the efficacy of fospropofol disodium in inhibiting the reaction of gastroscopy insertion[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(7): 908-912.

Figures/Tables 7

Table 1 Comparison of general data of three groups patients

Group	Age (years, $ \overline{x} $±s)	BMI (kg/m², $ \overline{x} $±s)	Examination time (min, $\overline{x} $±s)	Unconsciousness time (min, $\overline{x} $±s)	Recovery time (min, $\overline{x} $±s)	ASA (Ⅰ/Ⅱ)
Group M (n=32)	43.87±12.08	22.82±2.03	7.49±1.48	3.50±0.47	25.26±3.99	12/21
Group F (n=30)	43.41±11.54	22.89±2.05	7.51±1.46	3.54±0.48	25.20±4.00	16/14
Group C (n=29)	44.13±11.78	22.91±2.02	7.50±1.43	3.53±0.47	25.22±3.92	11/18

Fig.1 Sequential diagram of fospropofol disodium for painless gastroscopy in male patients when combined with nalbuphine

Fig.2 Dose-effect relationship of fospropofol disodium in male patients

Fig.3 Sequential diagram of fospropofol disodium for painless gastroscopy in female patients when combined with nalbuphine

Fig.4 Dose-effect relationship of fospropofol disodium in female patients

Fig.5 Sequential diagram of fospropofol disodium for painless gastroscopy when combined with nalbuphine

Fig.6 Dose-effect relationship of fospropofol disodium

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