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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2017, Vol. 22 ›› Issue (6): 709-712.

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Research on pharmacokinetics in weightless environment

WANG Xiaoqing 1,2, ZHOU Jiezhao 2, CHENG Zeneng 1, JIANG Dejian 2   

  1. 1 Pharmacy Department of Central South University School of Medicine,Engineering Technology Research Center for Optimization and Early Clinical Evaluation of Pharmaceutical Preparation in Hunan Province,Changsha 410013, Hunan, China; 2 Hunan Center for Safety Evaluation and Research of Drugs, Hunan Key Laboratory for Pharmacodynamics and Safety Evaluation of new drugs, Changsha 410013, Hunan, China
     
  • Received:2016-10-20 Revised:2017-01-04 Online:2017-06-26 Published:2017-06-26

Abstract:

Space pharmacokinetics is an important part of aerospace medicine. The change of pharmacokinetics caused by the change of physiological and biochemical function of weightlessness in space, is one of the key factors influencing the use of medicine. This article reviewed the research progress including experimental models, the effects on the absorption, distribution, metabolism and excretion of drugs, and the influencing factors of pharmacokinetics of weightlessness, which may provide some reference for space pharmacokinetics.

Key words: weightless, pharmacokinetics

CLC Number: