Abstract:

AIM: To investigate the preemptive analgesia effect of parecoxib sodium and its mechanism in pediatric laparoscopic appendectomy. METHODS: 60 children undergoing laparoscopic appendectomy under general anesthesia were randomly divided into experimental group and control group (n=30). The experimental group was intravenously injected with parecoxib sodium (1 mg/kg) 10 min before the anesthesia induction and the control group received equal amount of saline solution. VAS score was used to assess the degree of pain in postoperative children (non-coordinative children check the FLACC table); plasma prostaglandin E2 concentrations were measured before anesthesia induction (T0), end of operation (T1), 24 h after operation (T2) and 48 h after operation (T3). The incidence of postoperative complications such as restlessness, nausea and vomiting were observed in the two groups. The use of tramadol and the satisfaction degree of children or their families were observed 48 h after operation. RESULTS:Compared with the control group, the incidence of postoperative nausea, vomiting, agitation and the use rate of tramadol were lower in the experimental group；the satisfaction degree of the children or their families were higher than the control group 48 h after operation (P<0.05). Plasma prostaglandin E2 concentrations at T0, T1 and T2 increased in both groups, but the experimental group was higher than that of the control group (P<0.05). CONCLUSION: Pre-injection of parecoxib sodium before pediatric laparoscopic surgery can reduce the plasma concentration of prostaglandin E2 and alleviate postoperative pain as well as reduce the occurrence of postoperative nausea vomiting and restlessness.

Key words: parecoxib, children, laparoscopy surgery, preemptive analgesia