Abstract:

AIM: To investigate the serum miRNA-101 expression level in patients with newly diagnosed type 2 diabetes mellitus (T2DM), and to evaluate the clinical implications of miRNA-101 expression level variation. METHODS: qRT-PCR was used to determine the serum miRNA-101 expression level. Pearson correlation analysis was performed to observe the relationship between two variables. Multiple stepwise linear regression analysis was used to assess the association of serum miRNA-101 level and other parameters. RESULTS: Serum miRNA-101 level in patients with newly diagnosed T2DM was significantly higher than that in control subjects (P<0.05). The serum level of miRNA-101 was positively correlated with the glycosylated hemoglobin A1c (HbA1c, P<0.05). Multiple linear regression analysis revealed that the circulating miRNA-101 was in significant positive correlation with HbA1c (P<0.05) after adjustment for age, sex and body weight. CONCLUSION: Enhanced circulating miRNA-101 level in newly diagnosed T2DM patients may be associated with elevation of HbA1c.

Key words: newly diagnosed type 2 diabetes mellitus, glycosylated hemoglobin A1c, miRNA-101