Experimental studies of glutathione compound injection on anti-hepatic fibrosis in rats

Abstract

Abstract: AIM: To investigate the inhibitory action of glutathione compound injection on dimethylnitrosamine-induced hepatic fibrosis in rats.METHODS: The hepatic fibrosis model in rats were established by injection of dimethylnitrosamin.The liver function, levels of hyaluronic acid(HA),hepatic hydroxyproline(HYP) , transforming growth factor β-1(TGFβ-1) and the pathological change were detected.RESULTS: Compared with model group, glutathione compound injection could markedly improve the liver function, significantly decreased the levels of HA, HYP and TGFβ-1, the pathological changes could also be alleviated.CONCLUSION: Glutathione compound injection has protective effect against hepatic fibrosis ,the possible mechanism might be related to decreasing the level of TGFβ-1.

Key words: Dimethylnitrosamin, Hyaluronic acid, Hepatic hydroxyproline, Transforming growth factor β-1 , , , ,

CLC Number:

R965.1

LUO Sheng-yong,YE Shou-shan, MA Zheng, LI Xin-wei, JIA De-yun, NI Guang-yu. Experimental studies of glutathione compound injection on anti-hepatic fibrosis in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(1): 18-21.

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