Neutrophil gelatinase-associated lipocalin: a novel biomarker for the early diagnosis of acute kidney injury following adult cardiothoracic surgery

Abstract

Abstract: It is needed to develop early biomarkers of acute kidney injury following cardiac surgery, whose morbidity and mortality are increased by its presence. NGAL(neutrophil gelatinase-associated lipocalin) seems to be a promising biomarker for the early diagnosis of acute kidney injury (AKI). However, a wide range in its predictive value has been reported. It is reviewed whether NGAL can early diagnosis AKI actually.

Key words: Acute kidney injury, Neutrophil gelatinase-associated lipocalin, Biomarker, Cardiothoracic surgery

CLC Number:

R692

ZHANG Jin-bo, ZHANG Xiao-le, XU Guo-bin, DONG Zhi-bing, LI Chuan-guang, WANG Wen-long. Neutrophil gelatinase-associated lipocalin: a novel biomarker for the early diagnosis of acute kidney injury following adult cardiothoracic surgery[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(11): 1305-1309.

References

[1] Barratt J, Parajasingam R, Sayers RD,et al. Outcome of acute renal failure following surgical repair of ruptured abdominal aortic aneurysms[J]. Eur J Vasc Endovasc Surg,2000,20(2):163-168.
[2] Antunes PE, Prieto D, Ferrao de Oliveira J, et al. Renal dysfunction after myocardial revascularization[J]. Eur J Cardiothorac Surg,2004,25:597-604.
[3] Aronson S, Blumenthal R. Perioperative renal dysfunction and cardiovascular anesthesia: Concerns and controversies[J]. J Cardiothorac Vasc Anesth,1998,12(5): 567-586.
[4] Thakar CV, Yared JP, Worley S, et al. Renal dysfunction and serious infections after open-heart surgery[J]. Kidney Int, 2003, 64:239-246.
[5] Dimick JB, Pronovost PJ, Cowan JA, et al. Complications and costs after high-risk surgery: Where should we focus quality improvement initiatives[J] ? J Am Coll Surg, 2003, 196(5):671-678.
[6] Kheterpal S, Tremper KK, Englesbe MJ, et al. Predictors of postoperative acute renal failure after non cardiac surgery in patients with previously normal renal function[J]. Anesthesiology,2007, 107(6):892-902.
[7] Brienza N, Giglio MT, Marucci M, et al. Does perioperative hemodynamic optimization protect renal function in surgical patients? A meta-analytic study[J]. Crit Care Med, 2009,37(6):2079-2090.
[8] Tuladhar SM, Püntmann VO, Soni M, et al. Rapid detection of acute kidney injury by plasma and urinary neutrophil gelatinase-associated lipocalin after cardiopulmonary bypass[J]. J Cardiovasc Pharmacol, 2009, 53(3):261-266.
[9] Koyner JL, Bennett MR, Worcester EM, et al.Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery[J]. Kidney Int,2008,74(8):1059-1069.
[10] Tomas Berl. American society of nephrology renal research report[J]. J Am Soc Nephrol, 2005,16: 1886-1903.
[11] Herget-Rosenthal S, Marggraf G, Hu¨ sing J, et al. Early detection of acute renal failure by serum cystatin C[J]. Kidney Int,2004, 66:1115-1122.
[12] Mishra J, Dent C, Tarabishi R, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery[J]. Lancet,2005, 365(9466):1231-1238.
[13] Abu-Omar Y, Mussa S, Naik MJ, et al. Evaluation of cystatin C as a marker of renal injury following on-pump and off-pump coronary surgery[J]. Eur J Cardiothorac Surg,2005, 27(5):893-898.
[14] Stafford-Smith M, Podgoreanu M, Swaminathan M, et al. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery[J]. Am J Kidney Dis, 2005, 45(3):519-530.
[15] Wagener G, Jan M, Kim M, et al. Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery[J]. Anesthesiology, 2006, 105(3): 485-491.
[16] Cowland JB, Borregaard N. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans[J]. Genomics, 1997, 45(1): 17-23.
[17] Cowland JB, Sorensen OE, Schested M, et al. Neutrophil gelatinace-associatedocalin is up-regulated in human epithelial cells by IL-1β, but not by TNF-α[J]. J Immunol, 2003, 171; 9366-0366.
[18] Mishra J, Mori K, Ma Q ,et al. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin[J]. J Am Soc Nephrol,2004, 15: 3073-3082.
[19] Friedl A, Stoesz SP, Buckley P, et al. Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues:Cell type-specific pattern of expression[J]. Histochem J, 1999,31(7):433-441.
[20] Devarajan P. Neutrophil gelatinase-associated lipocalin-an emerging troponin for kidney injury[J]. Nephrol Dial Transplant, 2008,23(12):3737-3743.
[21] Capuano F, Goracci M, Luciani R, et al. Neutrophil gelatinase-associated lipocalin levels after use of mini-cardiopulmonary bypass system[J]. Interact Cardiovasc Thorac Surg, 2009,9(5):797-801.
[22] Xu SY, Petersson CG, Carlson M, et al. The development of an assay for human neutrophil lipocalin (HNL)-to be used as a specific marker of neutrophil activity in vivo and vitro[J]. J Immunol Methods,1994,171(2):245-252.
[23] Mishra J, Mori K, Ma Q, et al. Neutrophil gelatinaseassociated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity[J]. Am J Nephrol, 2004,24(3): 307-315.
[24] Kjeldsen L, Koch C, Arnljots K, et al. Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils[J]. J Immunol Methods,1996, 198(2): 155-164.
[25] Mishra J, Ma Q, Prada A, et al.Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury[J]. J Am Soc Nephrol,2003,14:2534-2543.
[26] Haase-Fielitz A, Bellomo R, Devarajan P, et al. Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery-a prospective cohort study[J]. Crit Care Med, 2009,37(2):553-560.
[27] Haase M, Bellomo R, Devarajan P, et al. Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults[J]. Ann Thorac Surg, 2009,88(1):124-130.
[28] Han WK, Wagener G, Zhu Y , et al. Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery[J]. Clin J Am Soc Nephrol, 2009, 4(5): 873-882.
[29] Xin C, Yulong X, Yu C, et al. Urine neutrophil gelatinase-associated lipocalin and interleukin-18 predict acute kidney injury after cardiac surgery[J]. Ren Fail, 2008, 30(9): 904-913.
[30] Wagener G, Gubitosa G, Wang S, et al. Urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery[J]. Am J Kidney Dis, 2008, 52(3):425-433.
[31] Cai L, Borowiec J, Xu S, et al. Assays of urine levels of HNL/NGAL in patients undergoing cardiac surgery and the impact of antibody configuration on their clinical performances[J]. Clin Chim Acta, 2009,403(1/2):121-125.
[32] Liangos O, Tighiouart H, Perianayagam MC, et al. Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass[J]. Biomarkers, 2009,14(6):423-431.