Effects of glutamine on experimental enterobrosis and severe infection treatment

Abstract

Abstract: AIM: To explore the effects of glutamine on experimental enterobrosis and severe infection in SD rats and compared to antibiotics. METHODS: 50 healthy female SD rats were randomly divided into five groups: sham operation group, model group, glutamine group(N(2)-L-Alanyl-L-glutamine), Cefamandole group, combined treatment group(N(2)-L-Alanyl-L-glutamine + Cefamandole sodium). Sham surgery were performed on sham operation group, experimental enterobrosis and severe infection rats model were established on other groups with CLP surgery. Control and model group received intraperitoneal injection of saline, other groups were treated with corresponding drugs. We examined the infection of abdominal cavity, blood cells, the serum concentration of lipopolysaccharide and phospholipase A₂. RESULTS: The index of model group were higher than control group(P<0.01), and the index of glutamine group, Cefamandole group, combined treatment group by N(2)-L-Alanyl-L-glutamine and Cefamandole sodium were lower than model group(P<0.01). CONCLUSION: Supplementary of glutamine is effective in treating severe infection caused by experimental enterobrosis and the effects is comparative with antibiotics. The combined treatment shows synergistic effect in treatment of enterobrosis and severe infection.

Key words: Glutamine, Severe infection, Enterobrosis, Endotoxin, Phospholipase A₂

CLC Number:

FAN Xiao, HE Liu-dang, XU Yang. Effects of glutamine on experimental enterobrosis and severe infection treatment[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(4): 410-415.

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