Abstract: AIM: To investigate the influence of different dose atorvastatin on the curative effect and restenosis in patients with acute myocardial infarction for postoperative percutaneous coronary intervention (PCI). METHODS: 162 patients with acute myocardial infarction for postoperative PCI were divided into Group A(atorvastatin 20 mg/d group) and Group B(atorvastatin 40 mg/d group), both of which were treated with atorvastatin for 12 months. Serum lipid, CRP, IL-6, NO, CGRP, ET-1, D%, liver function,renal function and CK were measured before PCI, 6 months and 12 months after PCI.In addition,the curative effects of atorvastatin,adverse cardiovascular outcomes and side effect of atorvastatin were observed. RESULTS: Compared with the Group A, the TC, LDL-C, CRP, IL-6, ET-1 were significantly reduced and the HDL-C, NO, CGRP, D% were improved in Group B after treatment(P<0.05), and there was no statistical difference(P＜0.05) with no severe side effect. In addition,the morbidity of restenosis after PCI in Group B was decreased, and there was no statistical difference(P＜0.05). CONCLUSION: High dose atorvastatin have a significantly anti-inflammatory effect and endothelial function improvement, decreasing significantly the morbidity of restenosis after PCI.

Key words: Atorvastatin, Myocardial infarction, Percutaneous coronary intervention, Restenosis