Abstract: AIM: To research the therapeutic and side effects of Seroquel in the treatment of elder schizophrenic patients. METHODS: Thirty schizophrenic patients were treated with Risperidone as the controlled group.The efficacy was measured with the positive and negative symptoms scale (PANSS), while the adverse events were determined by the treatment emergent symptoms scale (TESS). RESULTS: The efficacy rate of Risperidone was 78%,in which 39% were improved markedly. The efficacy rate of Seroquel was 88%, in which 76% were improved markedly. CONCLUSION: It is suggested that both drugs are effective exactly in the treatment of schizophrenic patients and fewer side effects.Seroquel appears to be more effective in improving psychiatric symptoms.

Key words: Seroquel, Risperidone, Schizophrenia