Changes of electrocardiogram induced by neurotoxin soman and rescue of benthiactzine in dogs

Abstract

Abstract: AIM:To investigate the changes of electrocardiogram(ECG), LDH and CK-MB caused by soman, and the therapeutic effects of benthiactzine. METHODS:7 healthy male dogs, weighing 12-15 kg, were given intramuscularly 1/3LD soman (1LD= 10 μg/kg)per ten minutes.The mean blood pressure lower than 40-45 mm Hg was defined as circulatory failure.The changes of ECG, heart rate, blood pressure, LDH and CK-MB were recorded either before and after soma was given or after benthiactzine was given. RESULTS:It was observed that decreased heart rate, A-V block, high and sharp T wave with or without P wave in ECG of dogs after soma was given.Meanwhile, the levels of CK-MB and LDH were increased significantly (P<0.05).The treatment of benthiactzine made the ECG recovery normal, but CK-MB and LDH did not obviously change.CONCLUSION:The cholinesterase inhibitor soman leads to serious arrhythmia which can be remedied by benthiactzine.

Key words: soman, benthiactzine, circulatory failure, ECG, dog

CLC Number:

R965

ZHANG Jin-jin, LONG Chao-liang, TANG Yuan, WANG Ru-huan, SONG Li-xue, WANG Hai, XIA Yun-feng. Changes of electrocardiogram induced by neurotoxin soman and rescue of benthiactzine in dogs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(8): 886-890.

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