Experimental study for antidepressant effects on the dose-effect relationship of Helicid derivate W0620

Abstract

Abstract: AIM: To investigate the dose-effect relationship of Helicid derivate W0620 for immobility time using the tail suspension test in mice. METHODS: Antidepressant effects of different dosage of W0620 were studied on the behavioral despair animal model-tail suspension test in mice, and the stimulative effects on the central nervous system (CNS) were observed by the autonomic activity test in mice. RESULTS: Four dose groups of W0620(5.91, 17.73, 53.20, 159.60 mg /kg) had no effects on autonomic activity in mice (P >0.05), and three dose groups of W0620(17.73, 53.20, 159.60 mg /kg) could significantly shorten the mice immobility time (P <0.01) compared with that of the control group. A sigmoid curvilinear relationship was shown between the logarithmic doses of W0620 and the antidepressant effects, the pharmacodynamic parameters were as follow: E_max 80.79 s, E_base 12.13 s, K 9.16 mg /kg, H 3.38, ED₅₀ 9.16 mg /kg, E₅₀ 46.46 s, ED₈₀ 13.81 mg /kg, E₈₀ 67.05 s, ED₉₀ 17.56 mg /kg, E₉₀ 73.92 s. CONCLUSION: W0620 has an obviously antidepressant effect whereas it has no inhibition action on CNS. There is a sigmoid curvilinear relationship between the logarithmic doses and the antidepressant effects.

Key words: Helicid, W0620, antidepressive agents, dose-effect relationship, tail suspension test in mice, automomic activity

CLC Number:

R965.2

TONG Jiu-cui, SUN Rui-yuan, JIANG Si-yan, YANG Bin, RUI Jia-liang, LI Juan, XIE Hai-tang. Experimental study for antidepressant effects on the dose-effect relationship of Helicid derivate W0620[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(11): 1277-1281.

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