Progress and thoughts on pharmacodynamics and pharmacokinetics of echinacoside

Abstract

Abstract: This review makes a summary on the pharmacological effects and involved mechanisms of echinacoside(ECH), including anti-aging, memory improvement, neuro-protective, anti-tumor, liver protective, and immunoloregulation. Besides, the advances in pharmacokinetics of ECH such as absorption and metabolism are also summarized.Based on such summaries, this paper furthers the discussions on the apparent contradiction between the observed pharmacological effects and pharmacokinetic behaviors of ECH. Based on the above, this paper points out the natural sourced innovative drugs were usually characterized on its extensively pre-system metabolism. The overall affection may be contributed by their active metabolites. To AIM directly at such characteristics of Type I the traditional Chinese medicine (TCM)new drugs, we should strengthen the research on pre-system metabolic transformation, as well as establishing scientific and reasonable preclinical pharmacokinetic guiding principle, to direct the research of Type I TCM new drugs with similar characteristics.

Key words: Echinacoside, Pharmacodynamics, Pharmacokinetics

CLC Number:

DAI Liang, HAO Hai-ping, WANG Yu-xin,WANG Guang-ji. Progress and thoughts on pharmacodynamics and pharmacokinetics of echinacoside[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(3): 342-349.

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