Association between heme oxygenase-1 gene promoter polymorphism and the susceptibility of human disease

Abstract

Abstract: Heme oxygenase-1(HO-1), the inducible isoform of heme oxygenase, is a cytoprotective enzyme that plays a central role in the defense against oxidative. HO-1 catalyzes the degradation of heme into iron, carbon monoxide (CO), and biliverdin, which is quickly converted into bilirubin. These downstream products of heme catabolism have recently been found to be some protective factors with potent anti-inflammatory, anti-oxidant, and anti-proliferative effects. Although HO-1 is expressed in various tissues at a low level, and is upregulated by multiple adverse stimuli, thus it plays an important role in keeping cell redox homeostasia under various pathophysiological conditions. From several studies it seems that two potentially function polymorphisms in the 5'-flanking region of human HO-1 gene promoter modulate the quantitative level of HO-1 activity, and the polymorphisms were shown to be associated with susceptibility to various disease, so the present article focuses on the role of this two polymorphisms on its function as well as disease susceptibility.

Key words: Heme oxygenase-1, Oxidative stress, Homeostasis, Promoter, Mutation

CLC Number:

R968

HOU Rui-ying, LIU Zhao-qian. Association between heme oxygenase-1 gene promoter polymorphism and the susceptibility of human disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(3): 335-341.

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