Abstract: AIM: To observe the preventive effects of aluminum phosphate gel and smectite powder on the side effects of erythromycin lactobionate via intervenous drop infusion for the gastrointestinal tract in children. METHODS: 249 cases children with mycoplasmal pneumonia were randomly divided into three groups, aluminum phosphate gel group, smectite powder group and control group, 83 cases in each group.The side effects of erythromycin lactobionate(abdominal pain, diarrhea, sicchasia, disgorging)for the gastrointestinal tract among three groups were observed.RESULTS: Compared with control group, the incidence rate of side effects was much lower in aluminum phosphate gel group and smectite powder group (P <0.01), which was lower in aluminum phosphate gel group than that in smectite powder group (P <0.05).There were no significant differences among the three groups (P > 0.05).CONCLUSION: Aluminum phosphate gel and smectite powder significantly decrease the side effects of erythromycin lactobionate for the gastrointestinal tract in children, and especially the former, can be widely applied in pediatric clinic.

Key words: aluminum phosphate gel, smectite powder, erythromycin lactobionate, gastrointestinal tract side effect