Bioactivity and function of BAM22

Abstract

Abstract: BAM22( Bovine adrenal medulla 22) is a peptide with 22 amino acids that is one of the cleavage products of proenkephalin A,-the precursor of Leu-and Met-enkephalin .It binds to μ-、δ-and κ-opioid receptors with a high affinity, and this binding is naloxone-displace- able .The BAM22 peptide exhibits opioid activities.It has been found recently that BAM22 also displays an affinity to novel “ orphan” G-protein-coupled receptors, named the sensory neuron-specific receptor ( SNSR) .The fact that SNSR is uniquely localized in the small sensory neu- rons of dorsal root ganglion renews interest for studying the peptide .The bioactivity and functions of BAM22 were re- viewed in this article.

Key words: BAM22 , opioid receptors , SNSR , opioid activities , non-opioid activities

CLC Number:

R338

CAI Mei-fang, HONG Yan-guo. Bioactivity and function of BAM22[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(2): 121-125.

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