Advancement of vanilloid receptor 1

Abstract

Abstract: Vanilloid receptor subtype 1 ( VR1) is a central molecule of injury sense.VR1 plays an important role in pain generation at central nerve system level, or at peripheral level ;further more, VR1 involves in many physiological actions and pathological processes .The acti- vated VR1 at the terminus of nerve can regulate blood pressure by affecting peripheral blood vessel contraction or relaxation .Activated VR1 can protect myocardium from ischemic injury .VR1 is also involved in asthma, gastric secretion, and gastrointestinal motility .Besides, VR1 ac- tivation can inhibit hair shaft growth, and induce tumor cells apoptosis .The concise report reviewed the advance- ment of VR1 research in recent years .

Key words: vanilloid receptor 1 , pain , blood pres- sure , asthma , apoptosis

CLC Number:

R285

CHEN Min, ZHANG Lu-yong, YAN Ming. Advancement of vanilloid receptor 1[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(2): 126-130.

References 1

1	Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor:a hea t - activated ion chan- nel in the pain pathway [ J] . Nature, 1997; 389 : 816-24
2	Philip H, Helen JM, Martin J, Gunthorpe MH, Harries D, Mal- colm D, William C, et al . Cloning and expression of a human or- thologue of rat vanilloid receptor-1[ J] . Pain, 2000; 88: 205 -15
3	Jeffrey W, Touchman YA, Nicde LD, Valerie V, Braden M, Geraldine MD, Vorasuk S, et al . The genomic region encompass- ing the nephropathic cystinosis gene ( CTNS) : complete sequenc- ing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion[ J] . Genome Res, 2000; 10: 165-73
4	Wood JN, Winter J, James IF, Rang HP, Yeats J, Bevan S.Cap- saicin induced ion fluxes in dorsal root ganglion cells in culture [ J] . J Neurosci, 1988 ; 8: 3208-20
5	Ricarda J, Mathias D, Clemens G, Olaf B, Jens K, Ferdinand H. Biochemical characterization of the vanilloid receptor 1 ex- pressed in a dorsal root ganglia derived cell line[ J] .Eur J. Biochem, 2001; 268: 5489 -96
6	Szallasi A.Autoradiographic visualization and pharmacological characterization of vanilloid ( capsaicin) receptors in several species, including man[ J] . Acta Physiol Scand, 1995 ; 155 : 1 -
	68
7	é va M, Zsuzsanna E.To′th, Daniel N.Distribution of mRNA for vanilloid receptor subtype 1 ( VR1) , and VR1-like immuno- reactivity, in the central nervous system of the rat and human [ J] . Proc Natl Acad Sci, 2000;97: 3655 -60
8	Birder LA, Kanai AJ, DeGroat WC, Kiss S, Nealan ML, Burke NE, et al . Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells [ J] .Proc Natl Acad Sci, 2001; 98: 13396 -401 · 128 · Chin J Clin Pharmacol Ther 2006 Feb; 11( 2)9 Reilly CA, Taylor JL, Lanza DL, Carr BA, Crouch DJ, Yost GS.Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors[ J] . Toxicol Sci, 2003 ;
73	: 170-82
10	B1′ ro′T, Maurer M, Modarres S, Lewin NE, Brodie C, A′cs G, et al . Characterization of functional vanilloid receptors expressed by mast cells[ J] . Blood, 1998; 91 : 1332-40
11	Southall MD, Li T, Gharibova LS, Pei Y, Nicol GD, Travers JB . Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes[ J] . J Phar- macol Exp, 2003; 304: 217 -22
12	Chen CW, Lee ST, Wu WT, Fu WM, Ho FM, Lin WW. Signal transduction for inhibition of inducible nitricoxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages[ J] .Br J Pharmacol, 2003 ; 140: 1077-87
13	Antonio FM, Carolina GM, Cruz MP.Molecular architecture of the vanilloid receptor[ J] . Eur J Biochem, 2004; 271 : 1820-6
14	John BD, Julie G, Martin JG, Jonathan PH, Phil TD, Philip O, et al . Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia[ J] . Nature, 2000 ; 405: 183-7
15	Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Pe- tersen-Zeitz KR, et al . Impaired nociception and pain sensation in mice lacking the capsaicin receptor[ J] . Science, 2000; 288 : 306 -13
16	Michael GJ, Priestly JV. Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downreguation by axotomy[ J] . J Neurosci, 1999; 19 : 1844-54
17	Perkins M, Dray A. Novel pharmacological strategies for analge- sia[ J] . Ann Rheun Dis, 1996; 55 : 715-8
18	Saoirse EO, David AK, Michael DR. Heterogeneity in the mech- anisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries[ J] . Br J Pharmacol, 2004; 142 : 435-42
19	Somnath M, Barry MC, Allyn CH.Anandamide-induced vaso- relaxation in rabbit aortic rings has two components:G protein dependent and independent[ J] .Am J Physiol Heart Circ Physi- ol, 2002; 282 : H2046 -54
20	Barbara M, Grzegorz K, Manfred G. Anandamide and methanan- damide induce both vanilloid VR1- and cannabinoid CB1 recep- tor-mediated changes in heart rate and blood pressure in anaes- thetized rats[ J] .Arch Pharmacol, 2001; 364: 562 -9
21	Paula JW, Smith, DS,McQueen. Anandamide induces cardiovas- cular and respiratory reflexes via vasosensory nerves in the an- aesthetized rat[ J] .Br J Pharmocl, 2001; 134: 655 -63
22	Matthew RZ, Li DP, Chen SR, Pan HL.Cardiac vanilloid recep- tor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats[ J] . J Physiol, 2003 ; 551: 515-23
23	Li YJ, Peng J. The cardioprotection of calcitonin gene-related peptide-mediated preconditioning[ J] .Eur J pharmacol, 2002 ; 442 : 173
24	Geraghty DP, Mazzone SB .Respiratory actions of vanilloid re- ceptor agonists in the nucleus of the solitary tract:comparison of resiniferatoxin with non-pungent agents and anandamide[ J] . Br J Pharmacol, 2002 ; 137: 919-27
25	Yanlin J, Robbie LM, Xin W, Leonard EP, Robert WE, John AH .Anandamide induces cough in conscious guinea-pigs through VR1 receptors[ J] . Br J Pharmacol, 2002 ; 137: 831-6
26	Tucker RC, Kagaya M, Page CP, Spina D. The endogenous can- nabinoid agonist, anandamide stimulates sensory nervesin guin- ea-pig airways[ J] . Br J Pharmacol, 2001 ; 132: 1127-35
27	Nielsen GD. Mechanisms of activation of the sensory irritant re- ceptor by airborne chemicals[ J] . Toxicology, 1991; 21 : 183 - 208
28	Agopy an N, Head J, Yu S, Simon1 SA . TRPV1 receptors mediate particulate matter-induced apoptosis[ J] . Am J Physiol Lung Cell Mol Physiol, 2004; 286 : 563-72
29	Jancso G, Kiraly E, Jancso-Gabor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons [ J] . Nature, 1997; 270: 741 -3
30	Zoltan O, Tamas S, Laszlo K, Chris HR, Douglas F, Robert MC, et al . Ligand-induced dynamic membrane changes and cell de- letion conferred by vanilloid receptor[ J] .J Biol Chem, 2001; 276: 11021-30
31	Mauro M, Tatiana L,Monica B, Gerry M, Alessandro FA. Anan- damide Induces Apoptosis in Human Cells via Vanilloid Recep- tors[ J] .J Biol Chem, 2000 ; 275: 31938-45
32	Emmanuel C, Mirna T, Vale′ rie S, Pelte MF, Dietricha PY. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1[ J] . Gynecologic Oncology, 2004; 93 : 93182 -8
33	Emmanuel C, Rick W, Mirna T, Belkouch MC, Valé rie S, Nico- las de T, et al .Arachidonylethanolamide Induces Apoptosis of Human Glioma Cells through Vanilloid Receptor-1[ J] . J Neuro- pathol Exp Neurol, 2004 ; 63: 956-63
34	Toshiyuki N, Junying Y.Cross-talk between two cysteine pro- tease families .Activation of caspase-12 by calpain in apoptosis [ J] . J Cell Biol, 2000 ; 150: 887-94
35	Enrique J, Roberto A, Marta A, Mar1′ a del CR, Antonio S, Carlos M, et al .Calcium Influx through Receptor-operated Channel Induces Mitochondria-triggered Paraptotic Cell Death [ J] .J Biol Chem, 2003; 278 : 14134 -45
36	Maria-Simonetta FP, Antonio T, Elisa B, Massimo L, Maria GV, Paolo B.Distribution of the vanilloid ( capsaicin) receptor type 1 in the human stomach[ J] . Histochem Cell Biol, 2005;DOI 10. 1007 s00418-005-0025 -9
37	Zittel TT, Meile T, Jehle EC, Becker HD. Intraperitoneal capsai- cin treatment reduces postoperative gastric ileus in awake rats [ J] . Langenbeck' s Arch Surg, 2001; 386: 204 -11
38	Bodo E, Biro T, Telek A, Czifra G, Griger Z, Toth BI, et al .A hot new twist to hair biology: involvement of vanilloid receptor-1 ( VR1 TRPV1) signaling in human hair growth control[ J] . Am J Pathol, 2005; 166: 985 -98
39	Gomtsyan A, Bayburt EK, Schmidt RG, Zheng GZ, Perner RJ, Didomenico S, et al .Novel transient receptor potential vanilloid
1	receptor antagonists for the treatment of pain:structure-activi- ty relationships for ureas with quinoline, isoquinoline, quinazo- line, phthalazine, quinoxaline, and cinnoline moieties[ J] . J Med Chem, 2005; 48 : 744-52

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